Structure and function of the glucocorticoid receptor
作者： Anthony P.H. Wright , Johanna Zilliacus , Iain J. McEwan , Karin Dahlman-Wright , Tova Almlöf
DOI: 10.1016/0960-0760(93)90052-X
关键词:
摘要: The glucocorticoid receptor protein is a transcriptional regulatory that interacts with specific enhancer sequences. A stoichiometric analysis of the interaction indicates an equimolar relationship between and activity itself regulated by binding glucocorticoids. two functional domains (DNA-binding steroid-binding) are adjacent lie within C-terminal half protein. N-terminal appears to modulate DNA but does not have any role in steroid. also been defined at sequence level.
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