The Cytoskeleton and Neuronal Disease

摘要: The presence of fibrillar intraneural structures was first recognized over 150 years ago. introduction, at the turn century, silver stains which reproducibly demonstrated linear “neurofibrils” in neuronal cytoplasm encouraged active neuropathological investigation into role these disease. This approach rapidly yielded results with description by Alzheimer an apparent thickening and in-crease number neurofibrils several cases presenile dementia. association premature loss recent memory persons middle age a specific lesion central nervous system is landmark correlation “mental” changes cellular pathology.