The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors

摘要: Recently, the genetic variant Y402H in CFH (complement factor H) gene was associated with an increased risk for MI (myocardial infarction) a prospective Caucasian cohort. In another nested case-control study, however, -Y402H did not carry susceptibility to MI. The aim of present study test association between and large sample familial background CAD (coronary artery disease). A total 2161 individuals from German family were studied by questionnaire, physical examination biochemical analyses. patients ( n =1188; 51.4±8.6 years at first MI) recruited families least two members affected and/or severe CAD. Spouses, sisters-in-law brothers-in-law respectively, without MI/CAD included as unaffected controls =973; 56.9±9.8 years). Genotyping performed using TaqMan assay. common classical cardiovascular factors (diabetes, hypercholesterolaemia, hypertension, obesity, smoking C-reactive protein serum levels). No found Separate analyses both men women revealed no gender-specific influence on or This investigation unable replicate our population which is enriched factors. We conclude that has relevant risk-modifying effect population.