Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine.
作者： Robert Ranaldi , Roy A. Wise
DOI: 10.1523/JNEUROSCI.21-15-05841.2001
关键词:
摘要: This study was designed to assess the involvement of D1 dopamine actions in ventral tegmental area (VTA) on intravenous cocaine self-administration. Rats were trained self-administer injections (1.0 mg/kg per injection) a fixed-ratio 1 (FR-1) schedule or progressive ratio (PR) reinforcement and then tested under influence bilateral VTA receptor antagonist SCH 23390 5-HT2 ketanserin. increased self-administration FR-1 but decreased it PR schedule. Injections ketanserin ineffective, as site mm dorsal rostral effective site. These data suggest role for dendritically released dopamine, presumably acting through receptors located axons GABAergic glutamatergic inputs VTA, effectiveness reward.
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