D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat.
作者： R. Maldonado , P. Robledo , A.J. Chover , S.B. Caine , G.F. Koob
DOI: 10.1016/0091-3057(93)90112-7
关键词:
摘要: Previous work using systemic injections of dopamine receptor antagonists has established that D1 receptors may have a role in cocaine self-administration. The purpose the present study was to test hypothesis these effects were mediated by region nucleus accumbens. Animals trained perform operant responses self-administer via an IV catheter on fixed-ratio 5 (FR 5) schedule reinforcement. SCH23390, selective antagonist, significantly increased self-administration when injected into This increase is thought reflect decreases magnitude reinforcer, similar observed dose reduced. Similar doses SCH23390 posterior caudate failed alter These data suggest accumbens are important for reinforcing properties cocaine.
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