CD163/CD16 coexpression by circulating monocytes/macrophages in HIV: potential biomarkers for HIV infection and AIDS progression.
作者： Tracy Fischer-Smith , Ellen M. Tedaldi , Jay Rappaport
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摘要: ABSTRACT Monocytes and macrophages play a prominent role in the establishment of HIV-1 infection, virus dissemination, development viral reservoirs. Like T cells, display immune polarization that can promote or impair adaptive immunity. We hypothesize dysregulation monocyte/macrophage activation differentiation may dysfunction contribute to AIDS pathogenesis. Using flow cytometry, we analyzed frequency monocyte subsets human immunodeficiency type 1 (HIV-1) infection relative seronegative controls, focusing on CD163+/CD16+ as likely precursor “alternatively activated” macrophage. Individuals with detectable showed an increase monocytes (CD14+) when compared HIV-1-infected persons undetectable loads. A positive correlation between increased load was revealed not seen ...
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