Hydrodynamics of segmentally flexible macromolecules.

摘要: Segmentally flexible macromolecules are composed of a few rigid subunits linked by joints which more or less flexible. The dynamics in solution this type macromolecule present special aspects that reviewed here. Three alternative approaches described. One is the rigid-body treatment, shown to be valid for overall dynamic properties such as translational diffusion and intrinsic viscosity. Another approach Harvey-Wegener particularly suited rotational diffusion. simplest version ignores hydrodynamic interaction (HI) effects, found quite accurate when compared rigorous including HI. A third Brownian simulation that, albeit at some computational cost, might describe rigorously cases arbitrary complexity. This technique has been used test approximations treatments, thus allowing better understanding their validity. trajectories simplified models trumbbell broken rod have simulated. comparison decay rates correlation functions with predictions two treatments leads general conclusion: treatment determines initial rate, while long-time behavior dominated relaxation time. As an example application specific biological macromolecule, we immunoglobulin molecule, showing how Dynamics can predict internal dynamics. typical myosin. Literature data whole myosin from treatments. situation problem on flexibility analyzed, indications given future experimental work.