Establishment and characterization of a biphasic synovial sarcoma cell line, SYO-1
作者： Akira Kawai , Noriko Naito , Aki Yoshida , Yuki Morimoto , Mamoru Ouchida
DOI: 10.1016/J.CANLET.2003.09.031
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摘要: We describe here the establishment of a new synovial sarcoma cell line, SYO-1, derived from biphasic that developed in groin 19-year-old female. The line was maintained for more than 70 passages (more 24 months) vitro. SYO-1 cells monolayer culture exhibited spindle shape without conspicuous pleomorphism. Immunohistochemically, were positive vimentin, type IV collagen, S-100, mdm2, bcl-2, c-Met and c-Kit. Tumors by their implantation nude mice histologically showed features composed areas fascicles compact proliferation polygonal to ovoid cells, which occasionally formed epithelial plaque expressed cytokeratin EMA. harbored characteristic t(X;18)(p11.2;q11.2) translocation chromosome analysis SYT-SSX2 chimeric transcript RT-PCR. first characterized retaining genetic phenotypic tumor, will be useful various investigations on sarcoma, especially its differentiation.
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