Activating transcription factor 2 in mesenchymal tumors.

摘要: Summary Activating transcription factor 2 (ATF2) is a member of activator protein 1 superfamily, which can heterodimerize with other factors regulating cell differentiation and survival. ATF2 assembles into complex the synovial sarcoma translocation, chromosome 18 (SS18)–synovial sarcoma, X breakpoint (SSX) fusion oncoprotein, transducin-like enhancer split (TLE1) corepressor, driving oncogenesis in sarcoma. The oncoproteins many translocation-associated sarcomas incorporate from ATF/cAMP response element binding or E26 families, potentially form heterodimers to regulate transcription. may therefore play an important role mesenchymal tumors, but as yet, little known about its expression patient specimens. Herein we perform immunohistochemical analyses using validated specific antibody for intracellular localization on cohort 594 malignant 207 benign tumors representing 47 diagnostic entities. Melanoma served positive control nuclear cytoplasmic staining. High was mainly observed and/or spindle including desmoplastic small round tumor, endometrial stromal gastrointestinal peripheral nerve sheath solitary fibrous tumor. Cytoplasmic less frequently seen than tumors. Benign mostly showed much lower expression.