NY-ESO-1 (CTAG1B) expression in mesenchymal tumors.
作者： Makoto Endo , Marieke A de Graaff , Davis R Ingram , Simin Lim , Dina C Lev
DOI: 10.1038/MODPATHOL.2014.155
关键词:
摘要: New York esophageal squamous cell carcinoma 1 (NY-ESO-1, CTAG1B) is a cancer-testis antigen and currently focus of several targeted immunotherapeutic strategies. We performed large-scale immunohistochemical expression study NY-ESO-1 using tissue microarrays mesenchymal tumors from three institutions in an international collaboration. A total 1132 intermediate malignant 175 benign lesions were enrolled this study. Immunohistochemical staining was on monoclonal antibody for NY-ESO-1. Among tumors, myxoid liposarcomas showed the highest positivity (88%), followed by synovial sarcomas (49%), myxofibrosarcomas (35%), conventional chondrosarcomas (28%). Positivity remaining consistently low, no immunoreactivity observed lesions. On basis these findings, nearly 90% liposarcomas, as well significant proportion sarcomas, myxofibrosarcomas, are good candidates immunotherapy targeting
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Christopher DM Fletcher, K Krishnan Unni, Fredrik Mertens, None, Pathology and genetics of tumours of soft tissue and bone IARC Press. ,(2002)
Aviad Hoffman, Markus P. H. Ghadimi, Elizabeth G. Demicco, Chad J. Creighton, Keila Torres, Chiara Colombo, Tingsheng Peng, Kristelle Lusby, Davis Ingram, Jason L. Hornick, Wei-Lie Wang, Vinod Ravi, Alexander J. Lazar, Dina Lev, Raphael E. Pollock, Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations. Cancer. ,vol. 119, pp. 1868- 1877 ,(2013) , 10.1002/CNCR.27847
Seth M Pollack, Achim A Jungbluth, Benjamin L Hoch, Erik A Farrar, Marie Bleakley, David J Schneider, Elizabeth T Loggers, Eve Rodler, Janet F Eary, Ernest U Conrad, III, Robin L Jones, Cassian Yee, NY-ESO-1 is a ubiquitous immunotherapeutic target antigen for patients with myxoid/round cell liposarcoma. Cancer. ,vol. 118, pp. 4564- 4570 ,(2012) , 10.1002/CNCR.27446
Yao T. Chen, Elisabeth Stockert, Marc Ladanyi, Lloyd J. Old, Achim A. Jungbluth, Cristina R. Antonescu, Klaus J. Busam, Kristin Iversen, Denise Kolb, Keren Coplan, Monophasic and biphasic synovial sarcomas abundantly express cancer/testis antigen NY-ESO-1 but not MAGE-A1 or CT7. International Journal of Cancer. ,vol. 94, pp. 252- 256 ,(2001) , 10.1002/IJC.1451
Elizabeth G Demicco, Keila E Torres, Markus P Ghadimi, Chiara Colombo, Svetlana Bolshakov, Aviad Hoffman, Tingsheng Peng, Judith V M G Bovée, Wei-Lien Wang, Dina Lev, Alexander J Lazar, Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma Modern Pathology. ,vol. 25, pp. 212- 221 ,(2012) , 10.1038/MODPATHOL.2011.148
Makoto Endo, Le Su, Torsten O. Nielsen, Activating transcription factor 2 in mesenchymal tumors. Human Pathology. ,vol. 45, pp. 276- 284 ,(2014) , 10.1016/J.HUMPATH.2013.09.003
SM Willems, YM Schrage, JJ Baelde, I Briaire‐de Bruijn, A Mohseny, Raphael Sciot, JVMG Bovee, PCW Hogendoorn, None, Myxoid tumours of soft tissue: the so-called myxoid extracellular matrix is heterogeneous in composition Histopathology. ,vol. 52, pp. 465- 474 ,(2008) , 10.1111/J.1365-2559.2008.02967.X
Marieke A. de Graaff, Anne-Marie Cleton-Jansen, Károly Szuhai, Judith V.M.G. Bovée, Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity. Human Pathology. ,vol. 44, pp. 1597- 1604 ,(2013) , 10.1016/J.HUMPATH.2013.01.006
Marina Pacheco, Torsten O Nielsen, Histone deacetylase 1 and 2 in mesenchymal tumors. Modern Pathology. ,vol. 25, pp. 222- 230 ,(2012) , 10.1038/MODPATHOL.2011.157
Jessica A Hemminger, Amanda Ewart Toland, Thomas J Scharschmidt, Joel L Mayerson, William G Kraybill, Denis C Guttridge, O Hans Iwenofu, The cancer-testis antigen NY-ESO-1 is highly expressed in myxoid and round cell subset of liposarcomas Modern Pathology. ,vol. 26, pp. 282- 288 ,(2013) , 10.1038/MODPATHOL.2012.133