Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations.

摘要: BACKGROUND. Myxoid liposarcoma (MLPS), a disease especially of young adults with potential for local recurrence and metastasis, currently lacks solid prognostic factors therapeutic targets. The authors this report evaluated the natural history outcome patients MLPS commonly deregulated protein biomarkers. METHODS. Medical records were retrospectively reviewed who presented to authors' institution localized (n = 207) or metastatic 61) (1990 2010). A tissue microarray patient specimens 169) was constructed immunohistochemical analysis molecular markers. RESULTS. The 5-year 10-year disease-specific survival rates among 93% 87%, respectively; male gender, age >45 years, recurrent tumor predicted poor outcome. rate 7.4%, risk associated tumors nonextremity location. Male gender main factor disease, which occurred in 13% patients. Forty percent had received chemotherapy, mostly neoadjuvant setting. Immunohistochemical revealed significantly higher expression C-X-C chemokine receptor type 4 (CXCR4) platelet-derived growth beta (PDGFR-β) lesions versus lesions. Tumors round cell phenotype expressed increased levels CXCR4, p53, adipophilin, PDGFR-α, PDGFR-β, vascular endothelial relative myxoid phenotype. Only tyrosine kinase encoded by AXL gene (AXL) identified as prognosticator univariate analysis. CONCLUSIONS. In study, clinical prognosticators well several Cancer 2013. © 2013 American Society.