Identification of a gene expression driven progression pathway in myxoid liposarcoma

摘要: // Loris De Cecco 1,* , Tiziana Negri 2,* Silvia Brich 2 Valentina Mauro Fabio Bozzi GianPaolo Dagrada Vittoria Disciglio 1 Roberta Sanfilippo 3 Alessandro Gronchi 4 Maurizio D’Incalci 5 Paolo G. Casali Silvana Canevari Marco A. Pierotti 6 and Pilotti Functional Genomics Bioinformatics, Department of Experimental Oncology Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Laboratory Pathology, Diagnostic Pathology Laboratory, Milan Adult Mesenchymal Tumor Medical Unit, Cancer Medicine Department, Surgery, Oncology, IRCCS, di Ricerche Farmacologiche Mario Negri, Scientific Directorate, * These authors contributed equally to this work Correspondence: Pilotti, email: Keywords : myxoid liposarcoma; progression round cell; gene expression array; epigenetic deregulation; stemness related genes; fast cell cycle genes Received April 25, 2014 Accepted: May Published: 27, Abstract Aim: investigate the events involved in liposarcoma (MLS). Gene profiling immunohistochemical/biochemical analyses were applied specimens representative opposite ends MLS spectrum: pure (ML) (RC) liposarcomas. The revealed involvement both coding non RNAs (SNORDs located DLK1-DIO3 region) support a model stepwise mainly driven by changes involving tumour vascular supply tumoral cellular component. In model, switch landscape from normal pro-angiogenic signature silencing region mark ML RC concert with acquisition latter over-expression YY1/C-MYC/HDAC2, together proliferation stemness: MKNK2 MSX1 TRIM71 . Taken together, these findings strongly suggest that progress cells have overcome restriction point order reset their new stem-like differentiation signature. Our provide first attempt at identifying missing links between liposarcomas, may also broader applications other clinico-pathological settings characterised spectrum progression.