Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity.

作者: Marieke A. de Graaff , Anne-Marie Cleton-Jansen , Károly Szuhai , Judith V.M.G. Bovée

DOI: 10.1016/J.HUMPATH.2013.01.006

关键词: Uterine leiomyomaCateninPathologyCarcinogenesisMutation testingWnt signaling pathwayCancer researchLeiomyosarcomaLeiomyomaBiologyMED12

摘要: … CDK8 module, which includes in addition to MED12 also MED13, CCNC (Cyclin C), and CDK8… The histologic diagnosis of all samples was confirmed by reviewing the hematoxylin and …

参考文章(34)
Christopher D.M. Fletcher, Krisjnan Unni, Fredrik Mertens, World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone IARC Press. ,(2002)
Chandrika Sreekantaiah, J. R. Davis, A. A. Sandberg, Chromosomal abnormalities in leiomyosarcomas. American Journal of Pathology. ,vol. 142, pp. 293- 305 ,(1993)
T Collins, C C Morton, A J Williams, W L Powell, HMGI(Y) expression in human uterine leiomyomata. Involvement of another high-mobility group architectural factor in a benign neoplasm. American Journal of Pathology. ,vol. 150, pp. 911- 918 ,(1997)
Sasha Akoulitchev, Sergei Chuikov, Danny Reinberg, TFIIH is negatively regulated by cdk8-containing mediator complexes Nature. ,vol. 407, pp. 102- 106 ,(2000) , 10.1038/35024111
P. Ramesh, S.R. Annapureddy, F. Khan, P.D. Sutaria, Angioleiomyoma: a clinical, pathological and radiological review. International Journal of Clinical Practice. ,vol. 58, pp. 587- 591 ,(2004) , 10.1111/J.1368-5031.2004.00085.X
Netta Mäkinen, Hanna-Riikka Heinonen, Shane Moore, Ian P.M. Tomlinson, Zephne M. van der Spuy, Lauri A. Aaltonen, MED12 exon 2 mutations are common in uterine leiomyomas from South African patients. Oncotarget. ,vol. 2, pp. 966- 969 ,(2011) , 10.18632/ONCOTARGET.370
R. Koivisto-Korander, J.I. Martinsen, E. Weiderpass, A. Leminen, E. Pukkala, Incidence of uterine leiomyosarcoma and endometrial stromal sarcoma in Nordic countries: Results from NORDCAN and NOCCA databases Maturitas. ,vol. 72, pp. 56- 60 ,(2012) , 10.1016/J.MATURITAS.2012.01.021
Erica Deutscher, Humphrey Hung-Chang Yao, Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis Developmental Biology. ,vol. 307, pp. 227- 236 ,(2007) , 10.1016/J.YDBIO.2007.04.036
Gaëlle Pérot, Sabrina Croce, Agnès Ribeiro, Pauline Lagarde, Valérie Velasco, Agnès Neuville, Jean-Michel Coindre, Eberhard Stoeckle, Anne Floquet, Gaëtan MacGrogan, Frédéric Chibon, MED12 Alterations in Both Human Benign and Malignant Uterine Soft Tissue Tumors PLoS ONE. ,vol. 7, pp. e40015- ,(2012) , 10.1371/JOURNAL.PONE.0040015
Carlos E de Andrea, Christianne MA Reijnders, Herman M Kroon, Daniëlle de Jong, Pancras CW Hogendoorn, Karoly Szuhai, Judith VMG Bovée, Secondary peripheral chondrosarcoma evolving from osteochondroma as a result of outgrowth of cells with functional EXT Oncogene. ,vol. 31, pp. 1095- 1104 ,(2012) , 10.1038/ONC.2011.311