Ketosis versus carbotoxicity - metabolism determines the outcome of cancer immunotherapy.

Federico Pietrocola, Jonathan Pol, Erika Vacchelli, Shuan Rao, David P. Enot, Elisa E. Baracco, Sarah Levesque, Francesca Castoldi, Nicolas Jacquelot, Takahiro Yamazaki, Laura Senovilla, Guillermo Marino, Fernando Aranda, Sylvère Durand, Valentina Sica, Alexis Chery, Sylvie Lachkar, Verena Sigl, Norma Bloy, Aitziber Buque, Simonetta Falzoni, Bernhard Ryffel, Lionel Apetoh, Francesco Di Virgilio, Frank Madeo, Maria Chiara Maiuri, Laurence Zitvogel, Beth Levine, Josef M. Penninger, Guido Kroemer, Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance Cancer Cell. ,vol. 30, pp. 147- 160 ,(2016) , 10.1016/J.CCELL.2016.05.016

Federico Pietrocola, Yohann Demont, Francesca Castoldi, David Enot, Sylvère Durand, Michaela Semeraro, Elisa Elena Baracco, Jonathan Pol, Jose Manuel Bravo-San Pedro, Chloé Bordenave, Sarah Levesque, Juliette Humeau, Alexis Chery, Didier Métivier, Frank Madeo, M. Chiara Maiuri, Guido Kroemer, Metabolic effects of fasting on human and mouse blood in vivo Autophagy. ,vol. 13, pp. 567- 578 ,(2017) , 10.1080/15548627.2016.1271513

Megan N. Roberts, Marita A. Wallace, Alexey A. Tomilov, Zeyu Zhou, George R. Marcotte, Dianna Tran, Gabriella Perez, Elena Gutierrez-Casado, Shinichiro Koike, Trina A. Knotts, Denise M. Imai, Stephen M. Griffey, Kyoungmi Kim, Kevork Hagopian, Marissa Z. McMackin, Fawaz G. Haj, Keith Baar, Gino A. Cortopassi, Jon J. Ramsey, Jose Alberto Lopez-Dominguez, A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice Cell Metabolism. ,vol. 26, pp. 539- 546.e5 ,(2017) , 10.1016/J.CMET.2017.08.005

John C. Newman, Anthony J. Covarrubias, Minghao Zhao, Xinxing Yu, Philipp Gut, Che-Ping Ng, Yu Huang, Saptarsi Haldar, Eric Verdin, Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice Cell Metabolism. ,vol. 26, pp. 547- 557.e8 ,(2017) , 10.1016/J.CMET.2017.08.004

Meenakshi Ravichandran, Gerald Grandl, Michael Ristow, Dietary Carbohydrates Impair Healthspan and Promote Mortality Cell Metabolism. ,vol. 26, pp. 585- 587 ,(2017) , 10.1016/J.CMET.2017.09.011

Lorenzo Galluzzi, Timothy A. Chan, Guido Kroemer, Jedd D. Wolchok, Alejandro López-Soto, The hallmarks of successful anticancer immunotherapy Science Translational Medicine. ,vol. 10, ,(2018) , 10.1126/SCITRANSLMED.AAT7807

Guido Kroemer, Carlos López-Otín, Frank Madeo, Rafael de Cabo, Carbotoxicity—Noxious Effects of Carbohydrates Cell. ,vol. 175, pp. 605- 614 ,(2018) , 10.1016/J.CELL.2018.07.044

Slaven Stekovic, Sebastian J. Hofer, Norbert Tripolt, Miguel A. Aon, Philipp Royer, Lukas Pein, Julia T. Stadler, Tobias Pendl, Barbara Prietl, Jasmin Url, Sabrina Schroeder, Jelena Tadic, Tobias Eisenberg, Christoph Magnes, Michael Stumpe, Elmar Zuegner, Natalie Bordag, Regina Riedl, Albrecht Schmidt, Ewald Kolesnik, Nicolas Verheyen, Anna Springer, Tobias Madl, Frank Sinner, Rafael de Cabo, Guido Kroemer, Barbara Obermayer-Pietsch, Jörn Dengjel, Harald Sourij, Thomas R. Pieber, Frank Madeo, Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans. Cell Metabolism. ,vol. 30, pp. 878- 881 ,(2019) , 10.1016/J.CMET.2019.07.016

Sarah Lévesque, Julie Le Naour, Federico Pietrocola, Juliette Paillet, Margerie Kremer, Francesca Castoldi, Elisa E. Baracco, Yan Wang, Erika Vacchelli, Gautier Stoll, Ariane Jolly, Pierre De La Grange, Laurence Zitvogel, Guido Kroemer, Jonathan G. Pol, A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice. OncoImmunology. ,vol. 8, ,(2019) , 10.1080/2162402X.2019.1657375

Gladys Ferrere, Maryam Tidjani Alou, Peng Liu, Anne-Gaëlle Goubet, Marine Fidelle, Oliver Kepp, Sylvère Durand, Valerio Iebba, Aurélie Fluckiger, Romain Daillère, Cassandra Thelemaque, Claudia Grajeda-Iglesias, Carolina Alves Costa Silva, Fanny Aprahamian, Deborah Lefevre, Liwei Zhao, Bernhard Ryffel, Emeline Colomba, Monica Arnedos, Damien Drubay, Conrad Rauber, Didier Raoult, Francesco Asnicar, Tim Spector, Nicola Segata, Lisa Derosa, Guido Kroemer, Laurence Zitvogel., Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade JCI insight. ,vol. 6, pp. 145207- ,(2021) , 10.1172/JCI.INSIGHT.145207