Analysis of polyfluoroalkyl substances and bisphenol A in dried blood spots by liquid chromatography tandem mass spectrometry
作者： Wanli Ma , Kurunthachalam Kannan , Qian Wu , Erin M. Bell , Charlotte M. Druschel
DOI: 10.1007/S00216-013-6787-3
关键词:
摘要: Dried blood spots (DBS), collected as part of the newborn screening program (NSP) in USA, is a valuable resource for studies on environmental chemical exposures and associated health outcomes newborns. Nevertheless, determination concentrations chemicals DBS requires assays with great sensitivity, typical volume available 16-mm diameter disc approximately 50 μL. In this study, we developed liquid-liquid extraction high-performance liquid chromatography/tandem mass spectrometry method detection perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), bisphenol A (BPA) DBS. The was validated accuracy, precision, by spiking target at different levels Whatman 903 filter cards, which used collection NSP. Contamination arising from collection, storage, handling an important issue to be considered analysis trace For evaluation magnitude background contamination, field blanks were prepared unspotted portions cards applied measurement PFOS, PFOA, BPA 192 specimens provided NSP New York State. PFOS PFOA detected 100 % analyzed. measured similar those reported earlier whole samples also found 86 ranging 0.2 36 ng/mL (excluding two outliers). Further are needed evaluate sources
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Henry M. Spliethoff, Lin Tao, Shannon M. Shaver, Kenneth M. Aldous, Kenneth A. Pass, Kurunthachalam Kannan, George A. Eadon, Use of Newborn Screening Program Blood Spots for Exposure Assessment: Declining Levels of Perfluorinated Compounds in New York State Infants Environmental Science & Technology. ,vol. 42, pp. 5361- 5367 ,(2008) , 10.1021/ES8006244
V Padmanabhan, K Siefert, S Ransom, T Johnson, J Pinkerton, L Anderson, L Tao, K Kannan, Maternal bisphenol-A levels at delivery: a looming problem? Journal of Perinatology. ,vol. 28, pp. 258- 263 ,(2008) , 10.1038/SJ.JP.7211913
Chunyang Liao, Kurunthachalam Kannan, High Levels of Bisphenol A in Paper Currencies from Several Countries, and Implications for Dermal Exposure Environmental Science & Technology. ,vol. 45, pp. 6761- 6768 ,(2011) , 10.1021/ES200977T
Kayoko Kato, Amal A. Wanigatunga, Larry L. Needham, Antonia M. Calafat, Analysis of blood spots for polyfluoroalkyl chemicals. Analytica Chimica Acta. ,vol. 656, pp. 51- 55 ,(2009) , 10.1016/J.ACA.2009.10.007
Nicole Riddell, Gilles Arsenault, Jonathan P. Benskin, Brock Chittim, Jonathan W. Martin, Alan McAlees, Robert McCrindle, Branched perfluorooctane sulfonate isomer quantification and characterization in blood serum samples by HPLC/ESI-MS(/MS). Environmental Science & Technology. ,vol. 43, pp. 7902- 7908 ,(2009) , 10.1021/ES901261V
José J. Pérez, Megan K. Williams, Gayanga Weerasekera, Kimberly Smith, Robin M. Whyatt, Larry L. Needham, Dana Boyd Barr, Measurement of pyrethroid, organophosphorus, and carbamate insecticides in human plasma using isotope dilution gas chromatography-high resolution mass spectrometry. Journal of Chromatography B. ,vol. 878, pp. 2554- 2562 ,(2010) , 10.1016/J.JCHROMB.2010.03.015
Samira Salihovic, Lisa Mattioli, Gunilla Lindström, Lars Lind, P. Monica Lind, Bert van Bavel, A rapid method for screening of the Stockholm Convention POPs in small amounts of human plasma using SPE and HRGC/HRMS Chemosphere. ,vol. 86, pp. 747- 753 ,(2012) , 10.1016/J.CHEMOSPHERE.2011.11.006
Maysa Faisal Suyagh, Godwill Iheagwaram, Prashant Laxman Kole, Jeff Millership, Paul Collier, Henry Halliday, James C. McElnay, Development and validation of a dried blood spot–HPLC assay for the determination of metronidazole in neonatal whole blood samples Analytical and Bioanalytical Chemistry. ,vol. 397, pp. 687- 693 ,(2010) , 10.1007/S00216-010-3571-5
Graham Lawson, Elizabeth Cocks, Sangeeta Tanna, Quantitative determination of atenolol in dried blood spot samples by LC-HRMS: a potential method for assessing medication adherence. Journal of Chromatography B. ,vol. 897, pp. 72- 79 ,(2012) , 10.1016/J.JCHROMB.2012.04.013
V. K. Dua, C. S. Pant, V. P. Sharma, G. K. Pathak, Determination of HCH and DDT in Finger-Prick Whole Blood Dried on Filter Paper and Its Field Application for Monitoring Concentrations in Blood Bulletin of Environmental Contamination and Toxicology. ,vol. 56, pp. 50- 57 ,(1996) , 10.1007/S001289900008