Anticancer drug discovery by targeting cullin neddylation

Dhulfiqar Ali Abed, Melanie Goldstein, Haifa Albanyan, Huijuan Jin, Longqin Hu, Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents. Acta Pharmaceutica Sinica B. ,vol. 5, pp. 285- 299 ,(2015) , 10.1016/J.APSB.2015.05.008

Peng Wu, Thomas E. Nielsen, Mads H. Clausen, Small-molecule kinase inhibitors: an analysis of FDA-approved drugs. Drug Discovery Today. ,vol. 21, pp. 5- 10 ,(2016) , 10.1016/J.DRUDIS.2015.07.008

Qiang Gao, Guang-Yang Yu, Jie-Yi Shi, Li-Hui Li, Wen-Juan Zhang, Zhi-Chao Wang, Liu-Xiao Yang, Meng Duan, Hu Zhao, Xiao-Ying Wang, Jian Zhou, Shuang-Jian Qiu, Lak Shin Jeong, Li-Jun Jia, Jia Fan, Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target Oncotarget. ,vol. 5, pp. 7820- 7832 ,(2014) , 10.18632/ONCOTARGET.2309

Lucía Barbier-Torres, Teresa C. Delgado, Juan L. García-Rodríguez, Imanol Zubiete-Franco, David Fernández-Ramos, Xabier Buqué, Ainara Cano, Virginia Gutiérrez-de Juan, Itziar Fernández-Domínguez, Fernando Lopitz-Otsoa, Pablo Fernández-Tussy, Loreto Boix, Jordi Bruix, Erica Villa, Azucena Castro, Shelly C. Lu, Patricia Aspichueta, Dimitris Xirodimas, Marta Varela-Rey, José M. Mato, Naiara Beraza, María L. Martínez-Chantar, Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer Oncotarget. ,vol. 6, pp. 2509- 2523 ,(2015) , 10.18632/ONCOTARGET.3191

Peng Wu, Thomas E. Nielsen, Mads H. Clausen, FDA-approved small-molecule kinase inhibitors Trends in Pharmacological Sciences. ,vol. 36, pp. 422- 439 ,(2015) , 10.1016/J.TIPS.2015.04.005

Margaret A. Read, James E. Brownell, Tatiana B. Gladysheva, Maria Hottelet, Lana A. Parent, Michael B. Coggins, Jacqueline W. Pierce, Vladimir N. Podust, Rong-Shu Luo, Vincent Chau, Vito J. Palombella, Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα Molecular and Cellular Biology. ,vol. 20, pp. 2326- 2333 ,(2000) , 10.1128/MCB.20.7.2326-2333.2000

Thomas Ried, Stanislas du Manoir, Thomas Cremer, Martin Reichel, Kelly Just, Almut Goeze, Günter Wolf, Anke Schwendel, Holger Langreck, Simone Petersen, Klaus Gellert, Michael Bujard, Manfred Dietel, Iver Petersen, Patterns of Chromosomal Imbalances in Adenocarcinoma and Squamous Cell Carcinoma of the Lung Cancer Research. ,vol. 57, pp. 2331- 2335 ,(1997)

Stephen R. Broderick, Benjamin J. Golas, Duykhanh Pham, Christopher W. Towe, Simon G. Talbot, Andrew Kaufman, Sarina. Bains, Laryssa A. Huryn, Yoshihiro Yonekawa, Diane Carlson, Dolores Hambardzumyan, Yegnanarayana Ramanathan, Bhuvanesh Singh, SCCRO Promotes Glioma Formation and Malignant Progression in Mice Neoplasia. ,vol. 12, pp. 476- 484 ,(2010) , 10.1593/NEO.10202

Daniel C. Scott, Vladislav O. Sviderskiy, Julie K. Monda, John R. Lydeard, Shein Ei Cho, J. Wade Harper, Brenda A. Schulman, Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8 Cell. ,vol. 157, pp. 1671- 1684 ,(2014) , 10.1016/J.CELL.2014.04.037

Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Darshan Sappal, Jessica Huck, Judy Shi, James Gavin, Jim Brownell, Yu Yang, Bradley Stringer, Robert Griffin, Frank Bruzzese, Teresa Soucy, Jennifer Duffy, Claudia Rabino, Jessica Riceberg, Kara Hoar, Anya Lublinsky, Saurabh Menon, Michael Sintchak, Nancy Bump, Sai M Pulukuri, Steve Langston, Stephen Tirrell, Mike Kuranda, Petter Veiby, John Newcomb, Ping Li, Jing Tao Wu, Josh Powe, Lawrence R Dick, Paul Greenspan, Katherine Galvin, Mark Manfredi, Chris Claiborne, Benjamin S Amidon, Neil F Bence, A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment Nature Medicine. ,vol. 24, pp. 186- 193 ,(2018) , 10.1038/NM.4474