Corneal Abnormalities Early in the Course of Fuchs' Endothelial Dystrophy

摘要: Purpose Corneas with advanced Fuchs' endothelial dystrophy that require keratoplasty manifest anterior corneal structural and cellular abnormalities have been associated visual deficits before after keratoplasty. In this study, we determined the onset of these in course disease. Design Cross-sectional study. Participants Sixty-three eyes (39 subjects) a range severity 25 (13 subjects) normal corneas. Methods All corneas were examined using slit-lamp biomicroscopy, ultrasonic pachymetry, confocal microscopy. The clinical grade was assessed according to presence extent guttae clinically evident edema categorized as mild (grades 1 2), moderate 3 4), or 5 6). Normal devoid any central (grade 0). Corneal backscatter (haze) measured from image light intensity profile. Stromal cell density number abnormal subepithelial cells images. Comparisons between groups made by generalized estimating equation models. Main Outcome Measures Anterior backscatter, stromal number, cells, thickness. Results 18% 67% higher compared ( P ≤ 0.003); similar trend noted  = 0.08). absolute 10% stroma approximately 20% 27% lower, respectively, (regardless severity) Conclusions begin early dystrophy, edema. chronicity changes can explain their incomplete resolution keratoplasty, understanding may help determine optimal time intervene achieve best outcomes.