IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?
作者： Jakub Tomala , Marek Kovar
DOI: 10.1080/2162402X.2015.1102829
关键词:
摘要: The in vivo biological activity of IL-2 can be dramatically increased by complexing with anti-IL-2 mAb. Moreover, IL-2/anti-IL-2 mAb immunocomplexes selectively stimulate different subsets immune cells, depending on the clone that is used. Thus, IL-2/S4B6 complexes strongly CD122high populations, namely NK and memory CD8+ T cells. They also intermediately Treg Conversely, IL-2/JES6.1 have no stimulatory for populations. However, they potently highly CD25+ cells (i.e., activated cells). been shown to possess antitumor various mouse tumor models.
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