摘要: There is a clear association between the development of breast cancer and increasing age, with 80% cancers occurring in women more than 50 years age one-third over 70 years. Following menopause undergoes involution, main changes affecting terminal ductal lobular unit. an increase oestrogen receptor alpha (ERα)-positive cells, decrease proliferation but, comparison to premenopausal breasts, greater number ERα-proliferating cells. The that occur ≥ 75 are likely be ER-positive, low growth rate limited expression HER-2 p53. It proposed uneven involution breast, persistence at-risk lesions, presence cells local metabolism adipose tissue factors well-differentiated phenotype. Copyright © 2007 Pathological Society Great Britain Ireland. Published by John Wiley & Sons, Ltd.
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