Chapter 2 Genes encoding the immunoglobulin constant regions
作者： Marianne Brüggemann
DOI: 10.1016/S0167-7306(08)60154-4
关键词:
摘要: Publisher Summary Antibody polypeptide chains are composed of domains with each domain consisting roughly 110 amino acids. There is a single variable region in both light and heavy chains. The constant the chain also (C, or C,), whereas has three four domains. depending upon class. Each domain, as well short hinge region, corresponds to separate exon DNA. Constant genes i n mouse human located on different chromosomes; C-region one cluster, whilst C, chromosomes. A major difference exists between expression genes. five antibody classes known man (IgM, IgD, IgG, IgE, IgA); class determined by expressed ( μ, δ, γ , ɛ α ) without regard chain. multiple for . In addition pseudogenes have been found immunoglobulin cluster.
sci-hub.se 参考文章(189)
H. Hayashida, T. Miyata, Y. Yamawaki-Kataoka, T. Honjo, J. Wels, F. Blattner, Concerted evolution of the mouse immunoglobulin gamma chain genes. The EMBO Journal. ,vol. 3, pp. 2047- 2053 ,(1984) , 10.1002/J.1460-2075.1984.TB02090.X
C. P. Milstein, A. Feinstein, Comparative studies of two types of bovine immunoglobulin G heavy chains Biochemical Journal. ,vol. 107, pp. 559- 564 ,(1968) , 10.1042/BJ1070559
P Brandtzaeg, Human secretory immunoglobulin M. An immunochemical and immunohistochemical study. Immunology. ,vol. 29, pp. 559- 570 ,(1975)
C.J. Word, J.F. Mushinski, P.W. Tucker, The murine immunoglobulin alpha gene expresses multiple transcripts from a unique membrane exon. The EMBO Journal. ,vol. 2, pp. 887- 898 ,(1983) , 10.1002/J.1460-2075.1983.TB01518.X
J.G. Flanagan, T.H. Rabbitts, The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes. The EMBO Journal. ,vol. 1, pp. 655- 660 ,(1982) , 10.1002/J.1460-2075.1982.TB01223.X
U. Krawinkel, T.H. Rabbitts, Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes. The EMBO Journal. ,vol. 1, pp. 403- 407 ,(1982) , 10.1002/J.1460-2075.1982.TB01182.X
S. Cory, M. Graham, E. Webb, L. Corcoran, J.M. Adams, Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene. The EMBO Journal. ,vol. 4, pp. 675- 681 ,(1985) , 10.1002/J.1460-2075.1985.TB03682.X
John Rogers, Randolph Wall, Immunoglobulin RNA Rearrangements in B Lymphocyte Differentiation Advances in Immunology. ,vol. 35, pp. 39- 59 ,(1984) , 10.1016/S0065-2776(08)60573-8
K L Knight, R C Burnett, J M McNicholas, Organization and polymorphism of rabbit immunoglobulin heavy chain genes. Journal of Immunology. ,vol. 134, pp. 1245- 1250 ,(1985)
D. M. Weir, Handbook of experimental immunology ,(1967)