Decreased ACTH secretion during prolonged transportation stress is associated with reduced pituitary responsiveness to tropic hormone stimulation in cattle
作者： Marlon Knights , George W. Smith
DOI: 10.1016/J.DOMANIEND.2006.09.001
关键词:
摘要: Abstract The present study examined the effect of transportation stress on hypothalamic–pituitary–adrenal axis responsiveness to tropic hormone stimulation and abundance corticotropin releasing factor (CRF) receptor R1 (CRFR1) arginine vasopressin (AVP) V3 (V3) mRNAs in anterior pituitary (AP) cattle. Holstein steers were transported for 10 h or used as non-transported controls (NTC). Blood samples collected at start every 1–2 h thereafter. To test AP hormones, animals challenged (i.v.) with CRF (0.5 μg/kg), AVP (1 μg/kg) plus immediately after end blood 30 min 3 h. 0, 4 harvested mRNA analyses. Plasma ACTH increased within 1 h remained elevated 6 8 h versus NTC 0 h values, respectively. concentrations cortisol response throughout transport period. Injection plasma ACTH, but secretion was dramatically reduced animals. following co-injection tended be less animals, almost 100% greater than when secretagogues administered separately. Despite decreased AVP, CRFR1 transportation. Results indicate may regulate duration
elsevier.com
sci-hub.se 参考文章(34)
D C Lay, T H Friend, R D Randel, O C Jenkins, D A Neuendorff, G M Kapp, D M Bushong, Adrenocorticotropic hormone dose response and some physiological effects of transportation on pregnant Brahman cattle. Journal of Animal Science. ,vol. 74, pp. 1806- 1811 ,(1996) , 10.2527/1996.7481806X
Greti Aguilera, Cristina Rabadan-Diehl, Regulation of vasopressin V1b receptors in the anterior pituitary gland of the rat. Experimental Physiology. ,vol. 85, ,(2000) , 10.1111/J.1469-445X.2000.TB00004.X
S. Gupta, B. Earley, S. T. L. Ting, N. Leonard, M. A. Crowe, Technical note: effect of corticotropin-releasing hormone on adrenocorticotropic hormone and cortisol in steers. Journal of Animal Science. ,vol. 82, pp. 1952- 1956 ,(2004) , 10.2527/2004.8271952X
G. A. Fernandes, P. Perks, N. K. M. Cox, S. L. Lightman, C. D. Ingram, N. Shanks, Habituation and Cross-Sensitization of Stress-Induced Hypothalamic-Pituitary-Adrenal Activity: Effect of Lesions in the Paraventricular Nucleus of the Thalamus or Bed Nuclei of the Stria Terminalis Journal of Neuroendocrinology. ,vol. 14, pp. 593- 602 ,(2002) , 10.1046/J.1365-2826.2002.00819.X
Hans Selye, The evolution of the stress concept. American Scientist. ,vol. 61, pp. 692- 699 ,(1973)
Ivana Škultétyová, Daniela Ježová, Dissociation of changes in hypothalamic corticotropin-releasing hormone and pituitary proopiomelanocortin mRNA levels after prolonged stress exposure. Molecular Brain Research. ,vol. 68, pp. 190- 192 ,(1999) , 10.1016/S0169-328X(99)00089-3
PETER C. WYNN, JAMES P. HARWOOD, KEVIN J. CATT, GRETI AGUILERA, Regulation of corticotropin-releasing factor (CRF) receptors in the rat pituitary gland: effects of adrenalectomy on CRF receptors and corticotroph responses Endocrinology. ,vol. 116, pp. 1653- 1659 ,(1985) , 10.1210/ENDO-116-4-1653
PETER C. SAKELLARIS, JOAN VERNIKOS-DANELLIS, Increased rate of response of the pituitary-adrenal system in rats adapted to chronic stress. Endocrinology. ,vol. 97, pp. 597- 602 ,(1975) , 10.1210/ENDO-97-3-597
George W Smith, Jean-Michel Aubry, Francoise Dellu, Angelo Contarino, Louise M Bilezikjian, Lisa H Gold, Ruoping Chen, Yelena Marchuk, Chris Hauser, Cornelia A Bentley, Paul E Sawchenko, George F Koob, Wylie Vale, Kuo-Fen Lee, Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron. ,vol. 20, pp. 1093- 1102 ,(1998) , 10.1016/S0896-6273(00)80491-2
M. Senn, P.M. Maier, W. Langhans, ACTH, cortisol and glucose responses after administration of vasopressin in cattle and sheep. Journal of Comparative Physiology B-biochemical Systemic and Environmental Physiology. ,vol. 164, pp. 570- 578 ,(1995) , 10.1007/BF00261398