Molecular spectrum of pigmented skin lesions: from nevus to melanoma

摘要: Melanoma develops through a series of architectural and phenotypically distinct stages becomes progressively aggressive, culminating in metastatic disease. Considerable progress has been made understanding the biological, pathological immunological aspects human melanoma progression. However, diagnosis, prognosis treatment remain challenging tasks owing to heterogeneous complex nature molecular aberrations. By incorporating new technology, key genes, involving signal pathways malignant transformation progression, continue be uncovered. This revolutionizes current concepts etiology pathogenesis introduces most diagnostic prognostic techniques, as well potential therapeutic approaches. A significant breakthrough is discovery role BRAF mutation development including important pathway during development, MAPK pathway. Addi...