Predictive value of rectal aberrant crypt foci for intraepithelial neoplasia in ulcerative colitis - a cross-sectional study.
作者： Paulo Freire , Pedro Figueiredo , Ricardo Cardoso , Maria Manuel Donato , Manuela Ferreira
DOI: 10.3109/00365521.2014.951390
关键词:
摘要: AbstractBackground. Ulcerative colitis (UC) is associated with an increased risk of colorectal cancer (CRC). Aberrant crypt foci (ACF) are important biomarkers sporadic CRC risk. Their correlation the intraepithelial neoplasia (IN) in UC remains unclear. Aims. To assess whether ACF a factor for IN long-standing and to investigate any between clinico-epidemiological characteristics prevalence/number these patients. Methods. Seventy-six patients were prospectively screened by colonoscopy chromoendoscopy-guided endomicroscopy. sought lower rectum. Results. Eight INs detected seven (9.2%) The prevalence mean number 60.5% 2.4 ± 2.8, respectively. was independently having (odds ratio = 1.338; 95% confidence interval 1.030–1.738). revealed good calibration (area under receiver operating characteristic curve 0...
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