Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase.
作者： Sundarraj Jayakumar , R.S. Patwardhan , Debojyoti Pal , Deepak Sharma , Santosh K. Sandur
DOI: 10.1016/J.BBRC.2016.06.144
关键词:
摘要: Dimethoxycurcumin (DIMC), a structural analogue of curcumin, has been shown to have more stability, bioavailability, and effectiveness than its parent molecule curcumin. In this paper the radiosensitizing effect DIMC investigated in A549 lung cancer cells. As compared showed very potent as seen by clonogenic survival assay. combination with radiation significantly increased apoptosis mitotic death This combinatorial treatment also lead effective elimination stem Further, there was significant increase cellular ROS, decrease GSH GSSG ratio slowdown DNA repair when combined radiation. silico docking studies vitro inhibition thioredoxin reductase enzyme DIMC. Overexpression abrogation underscoring role radiosensitization. Our results clearly demonstrate that can synergistically enhance cell killing targeting system.
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