Molecular heterogeneity in prostate cancer: can TP53 mutation unravel tumorigenesis?

摘要: While prostate cancer is the most common malignant visceral neoplasm of men, its etiology remains largely unknown and clinical course unpredictable. Molecular genetics has become a fruitful area investigation might provide clues to understanding these phenomena. Mutation TP53 tumor suppressor gene (encoding p53 protein) been commonly reported as critical event in human carcinogenesis, but recent findings research call into question correlation between mutation prognosis for patients with this tumor. Whole-mount analysis begun address histologic significance focal evolution pre-existing reveal role throughout process progression. This model also apply other tumors.