High Concentrations of a Novel Peptide, Neuropeptide Y, in the Innervation of Mouse and Rat Heart'
作者： J Gu , J M Polak , J M Allen , W M Huang , M N Sheppard
DOI: 10.1177/32.5.6546942
关键词:
摘要: A newly discovered bioactive peptide, neuropeptide Y (NPY), has been found in the innervation of mouse and rat heart by immunocytochemistry, NPY-immuno-reactive nerves were very dense around nodal tissues. They also surrounded coronary arteries arterioles close association with cardiac muscle. The distribution NPY-containing paralleled that noradrenergic fibers, demonstrated use antibodies to catecholamine-converting enzymes tyrosine hydroxylase dopamine beta-hydroxylase. Furthermore, NPY was seen be present a proportion intrinsic neurons mostly atria proximity tissue. concentrations extractable NPY-immunoreactive material (about 150 pmol/g whole heart) far surpasses those other peptides so reported High performance liquid chromatography immunoreactivity elute single sharp peak, an identical position brain NPY.
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