Lupus nephritis: correlation of interstitial cells with glomerular function.

摘要: Lupus nephritis: Correlation of interstitial cells with glomerular function. Mononuclear inflammatory were studied using monoclonal antibodies in the interstitium and glomeruli 35 renal biopsy specimens from patients lupus nephritis already taking immunosuppressants. The aims this study to assess composition significance infiltrate, correlations immediate function ability predict future course disease. majority T lymphocytes monocytes/macrophages. number CD4 +ve helper/ inducer was greater than that CD8 cytotoxic/ suppressor only 19 out biopsies, mean CD4:CD8 ratio being 1.5 ± 1.2. NK B a minor component only. Some expression IL-2, transferrin C3b receptors seen on cells, but HLA-DR expressing much excess controls tubular also increased. monocytes/macrophages highly correlated extent chronic damage judged by optical microscopy. There an association between at numbers DR cells. Subsequent decline function, however, associated rather small receptor-positive presence tubulointerstitial immune aggregates Ig and/or C 63% As previously described, degree chronicity index based No found or types (mostly monocyte/macrophages) intraglomerular leukocytes clinical features, except more proliferative showed leukocyte numbers. One hypothesis consistent our findings is monocytes may be important determinants pathogenesis progression nephritis. While several mechanisms play initial role, major factor injury.