Effect of rifampicin treatment on hepatic drug metabolism and serum bile acids in patients with primary biliary cirrhosis.

摘要: Six patients with primary biliary cirrhosis (PBC) were treated a daily oral dose of 600 mg rifampicin for 2 weeks to induce the hepatic metabolism drugs and bile acids. On 5 6 experienced pronounced decrease their pruritus. In all oxidative cytochrome P-450 dependent drug was induced as shown by an increase antipyrine-clearance from 36.3±8.8 80.6±20.1 ml/min enhanced urinary excretion 6-β-hydroxycortisol 454±1.99 1607±362 µg/24 h. Furthermore, in serum alkaline phosphatase declined. 3 cholestatic (bilirubin>1.0 mg/dl) concentration total conjugated acids strikingly reduced. Thus, is inducer PBC-patients, ameliorates pruritus can lower concentrations