Risk factors for cervical intraepithelial neoplasia.

摘要: To evaluate risk factors for cervical intraepithelial neoplasia (CIN), data were collected in a case-control study based on 366 patients (58 with CIN class 1, 70 2, and 238 3) 323 control subjects normal smears interviewed selected days at the same screening clinics where cases had been identified. No relationship emerged between indicators of socioeconomic status (education social class) mild/moderate (considered together) severe dysplasia. A total 55 (43%) 1 or 107 (45%) 3, 94 (29%) controls current smokers. The corresponding relative (RR) estimates versus never smokers 1.9 (95% confidence interval [CI] 1.2 to 3.0) 2 2.5 CI 1.7 3.6) increased number cigarettes smoked per day. was observed oral contraceptive use, parity, spontaneous induced abortions CIN, but tended report earlier age first birth than subjects. Compared women reporting their before 20 years, 0.5 0.4, respectively, 3 24 years age. 0.6 those 25 later, trends not statistically significant. sexual partners directly associated both histopathologic subgroups. no intercourse after 22 age, 18 RR estimate 2.3 2.4, being This confirms considerable similarities epidemiology In addition, it suggests consistency invasive that are likely act one stages process carcinogenesis (i.e., indications habits) differences hormone-mediated reproductive variables contraceptives).