作者: Isabelle M. Germano , Lawrence H. Pitts , Brian S. Meldrum , Henry M. Bartkowski , Roger P. Simon
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摘要: Pharmacological inhibition of excitatory neurotransmission attenuates cell death in models global ischemia/reperfusion and hypoglycemia. The current investigations extend these observations to a model focal ischemia. Kynurenic acid, broad-spectrum antagonist at amino acid receptors, was used as treatment (300 mg/kg; 3 doses 4-hour intervals) before after cerebral ischemia rats (n = 54). Preischemia but not 1 hour postischemia with kynurenate attenuated infarction size (p less than 0.001) improved neurological outcome studied 24 hours injury. These data support the role acute neuronal injury pharmacological excitation potential therapy for stroke.