Clinical and behavioural characteristics of self-isolating healthcare workers during the COVID-19 pandemic: a single-centre observational study

作者: Angus de Wilton , Eliz Kilich , Zain Chaudhry , Lucy CK Bell , Joshua Gahir

DOI: 10.1101/2020.05.07.20094177

关键词:

摘要: Objectives:To describe a cohort of self-isolating healthcare workers (HCWs) with presumed COVID-19. Design: A cross-sectional, single-centre study. Setting: large, teaching hospital based in Central London tertiary infection services. Participants: 236 HCWs completed survey distributed by internal staff email bulletin. 167 were female and 65 male. Measures: Information on symptomatology, exposures health-seeking behaviour collected from participants self-report. Results: The respondents reported illness compatible COVID-19 there was an increase reporting during March 2020. Diagnostic swabs not routinely performed. Cough (n=179, 75.8%), fever (n=138, 58.5%), breathlessness (n=84, 35.6%) reported. Anosmia 42.2%. Fever generally settled within 1 week (n=110, 88%). Several remained at home did seek formal medical attention despite severe measuring hypoxia (n=5/9, 55.6%). 2 patients required admission but recovered following oxygen therapy. 84 (41.2%) greater than the obligated 7 days off work 9 3 weeks off. Conclusion: There significant possible Conclusions cannot be drawn about exact numbers confirmed cases due to lack diagnostic swabbing. anosmia; as well early non-specific prior onset cough fever. This may represent pre-symptomatic who are likely infectious thus criteria for isolation swabbing should broadened. study also revealed concerning seeking red flag symptoms (severe breathlessness, hypoxia). addressed urgently reduce risk disease being detected late. Finally, this inform trusts that require longer recover illness.

参考文章(9)
Wei-jie Guan, Zheng-yi Ni, Yu Hu, Wen-hua Liang, Chun-quan Ou, Jian-xing He, Lei Liu, Hong Shan, Chun-liang Lei, David S.C. Hui, Bin Du, Lan-juan Li, Guang Zeng, Kwok-Yung Yuen, Ru-chong Chen, Chun-li Tang, Tao Wang, Ping-yan Chen, Jie Xiang, Shi-yue Li, Jin-lin Wang, Zi-jing Liang, Yi-xiang Peng, Li Wei, Yong Liu, Ya-hua Hu, Peng Peng, Jian-ming Wang, Ji-yang Liu, Zhong Chen, Gang Li, Zhi-jian Zheng, Shao-qin Qiu, Jie Luo, Chang-jiang Ye, Shao-yong Zhu, Nan-shan Zhong, Clinical Characteristics of Coronavirus Disease 2019 in China The New England Journal of Medicine. ,vol. 382, pp. 1708- 1720 ,(2020) , 10.1056/NEJMOA2002032
Marjolein F.Q. Kluytmans-van den Bergh, Anton G.M. Buiting, Suzan D. Pas, Robbert G. Bentvelsen, Wouter van den Bijllaardt, Anne J.G. van Oudheusden, Miranda M.L. van Rijen, Jaco J. Verweij, Marion P.G. Koopmans, Jan A.J.W. Kluytmans, SARS-CoV-2 infection in 86 healthcare workers in two Dutch hospitals in March 2020 medRxiv. ,(2020) , 10.1101/2020.03.23.20041913
Ya‐nan Han, Zhan‐wei Feng, Li‐na Sun, Xiao‐xia Ren, Hua Wang, Yong‐ming Xue, Yi Wang, Ying Fang, A comparative-descriptive analysis of clinical characteristics in 2019-coronavirus-infected children and adults. Journal of Medical Virology. ,vol. 92, pp. 1596- 1602 ,(2020) , 10.1002/JMV.25835
Tang Yifan, Liu Ying, Gao Chunhong, Song Jing, Wang Rong, Li Zhenyu, Gu Zejuan, Liao Peihung, Symptom Cluster of ICU Nurses Treating COVID-19 Pneumonia Patients in Wuhan, China. Journal of Pain and Symptom Management. ,vol. 60, ,(2020) , 10.1016/J.JPAINSYMMAN.2020.03.039
François Bénézit, Paul Le Turnier, Charles Declerck, Cécile Paillé, Matthieu Revest, Vincent Dubée, Pierre Tattevin, Cédric Arvieux, Marion Baldeyrou, Jean-Marc Chapplain, Pauline Comacle, Solène Patrat-Delon, Anne Maillard, Mélanie Poinot, Charlotte Pronier, Faouzi Souala, Vincent Thibault, Pierre Abgueguen, Hélène Cormier, Valérie Delbos, Marine de la Chapelle, Alexandra Ducancelle, Rafael Mahieu, Valérie Rabier, Sami Rehaiem, Yves Vandamme, Charlotte Biron, Jeanne Brochon, David Boutoille, Marie Chauveau, Colin Deschanvres, Benjamin J Gaborit, Joël Jenvrin, Raphaël Lecomte, Maeva Lefebvre, François Raffi, Utility of hyposmia and hypogeusia for the diagnosis of COVID-19. Lancet Infectious Diseases. ,vol. 20, pp. 1014- 1015 ,(2020) , 10.1016/S1473-3099(20)30297-8
Ling Mao, Huijuan Jin, Mengdie Wang, Yu Hu, Shengcai Chen, Quanwei He, Jiang Chang, Candong Hong, Yifan Zhou, David Wang, Xiaoping Miao, Yanan Li, Bo Hu, Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurology. ,vol. 77, pp. 683- 690 ,(2020) , 10.1001/JAMANEUROL.2020.1127
Ewan Hunter, David A Price, Elizabeth Murphy, Ina Schim van der Loeff, Kenneth F Baker, Dennis Lendrem, Clare Lendrem, Matthias L Schmid, Lucia Pareja-Cebrian, Andrew Welch, Brendan A I Payne, Christopher J A Duncan, First experience of COVID-19 screening of health-care workers in England. The Lancet. ,vol. 395, ,(2020) , 10.1016/S0140-6736(20)30970-3
Jon Brassey, Carl Heneghan, Tom Jefferson, SARS-CoV-2 viral load and the severity of COVID-19 ,(2020)