SARS-CoV-2 infection in 86 healthcare workers in two Dutch hospitals in March 2020

摘要: Background On February 27, 2020, the first patient with COVID-19 was reported in Netherlands. During following weeks, nine healthcare workers (HCWs) were diagnosed two Dutch teaching hospitals, eight of whom had no history travel to China or Northern-Italy. A low-threshold screening regimen implemented determine prevalence and clinical presentation among HCWs these hospitals. Methods HCWs who suffered from fever respiratory symptoms voluntarily tested for SARS-CoV-2 by real-time reverse-transcriptase PCR on oropharyngeal samples. Structured interviews conducted document all confirmed COVID-19. Findings Thirteen-hundred fifty-three (14%) 9,705 employed tested, 86 (6%) infected SARS-CoV-2. Most relatively mild disease only 46 (53%) fever. Seventy-nine (92%) met a case definition and/or coughing shortness breath. None identified through Northern Italy, 3 (3%) have been exposed an inpatient known prior onset symptoms. Interpretation Within weeks after detected, substantial proportion SARS-CoV-2, probably caused acquisition virus community during early phase local spread. The high presentations, frequently not including fever, asks less stringent use currently recommended case-definition suspected COVID-19.