The effect of intracellular antioxidant delivery (catalase) on hydrogen peroxide and proinflammatory cytokine synthesis: a new therapeutic horizon
作者： Rodney C. Siwale , George K. Yeboah , Richard Addo , Carl W. Oettinger , Martin J. D’Souza
DOI: 10.3109/10611860903161328
关键词:
摘要: Reactive oxygen species synthesized by endothelial cells may be responsible for cell damage and altered physiologic function. After endotoxin stimulation, free radicals including H2O2 are produced. We have developed a method of intracellular drug delivery using albumin microcapsules. Catalase would an excellent compound to alter production. However, the large molecular size catalase limits cellular penetration. Endothelial been previously shown readily phagocytoze microcapsules.Methods: was added solution form 10% catalase. Microspheres from 2 7 μm in were formed Bucchi spray dryer. Human incubated with varying concentrations microencapsulated The then exposed Escherichia coli determine if increased penetration inhibit H2O2, nitrate, cytokine synthesis.Results: There 7.2-fold increase c...
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