Potentiation of pro-inflammatory cytokine suppression and survival by microencapsulated dexamethasone in the treatment of experimental sepsis

摘要: Cytokine inhibiting drugs are much more effective when delivered intracellularly to phagocytic cells in the microencapsulated form. Dexamethasone is a powerful inhibitor of TNF-α cytokine through inhibition NF-κB which gene regulator multiple pro-inflammatory cytokines. We have determined effect dexamethasone release both vitro using whole blood model, and vivo peritonitis model septic shock. Microspheres 1–4 μm mean size were prepared by albumin polymer matrix one-step spray drying method. Microencapsulated form with concentration 10−1, 10−2 10−3 M was compared an equivalent solution model. The results show inhibited tumor necrosis factor-alpha (TNF-α) interleukin-beta (IL-1β) significantly comparison dexamethasone. also de...