Anti-hcv monoclonal antibody as a medicament for the therapeutic treatment and prevention of hcv infections
作者： Massimo Clementi , Roberto Burioni
DOI:
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摘要: The present invention relates to the monoclonal antibody e20 or a functional fragment thereof as medicament for therapeutic treatment and prevention of HCV infections. is able bind all known genotypes exhibits strong neutralising activity against virus, in particular towards Ia, Ib, 2a, 4. A pharmaceutical composition also described infections, which comprises thereof, pharmaceutically acceptable excipients, carriers diluents.
google.com.sb参考文章(66)
Lipatov As, Gitelman Ak, Claas Ec, Okuno Y, Van Beek R, Osterhaus Ad, Smirnov Ya, An epitope shared by the hemagglutinins of H1, H2, H5, and H6 subtypes of influenza A virus. Acta Virologica. ,vol. 43, pp. 237- ,(1999)
C. Chen, V.A. Roberts, S. Stevens, M. Brown, M.P. Stenzel-Poore, M.B. Rittenberg, Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations. The EMBO Journal. ,vol. 14, pp. 2784- 2794 ,(1995) , 10.1002/J.1460-2075.1995.TB07278.X
David M. Knight, Margaret McDonough, Maria Arevalo Moore, David Abercrombie, Richard Siegel, John Ghrayeb, Stable expression of cloned human antibody genes in murine myeloma cells. Human antibodies. ,vol. 3, pp. 129- 136 ,(1992) , 10.3233/HAB-1992-3303
Massimo Clementi, Roberto Burioni, Monoclonal Antibodies Capable of Reacting with a Plurality of Influenza Virus A Subtypes ,(2009)
Eduardo A. Padlan, Chantal Abergel, Jennifer P. Tipper, Identification of specificity-determining residues in antibodies. The FASEB Journal. ,vol. 9, pp. 133- 139 ,(1995) , 10.1096/FASEBJ.9.1.7821752
Massimo Clementi, Roberto Burioni, Method For The Preparation Of New Oligoclonal Antibodies ,(2008)
Suchismita Chattopadhyay, S. Müller, Hai-Tao Wang, H. Kohler, Srinivas-Venkatesh Kaveri, Generation and specificity of monoclonal anti-idiotypic antibodies against human HIV-specific antibodies. I. Cross-reacting idiotopes are expressed in subpopulations of HIV-infected individuals. Journal of Immunology. ,vol. 147, pp. 933- 941 ,(1991)
K Hariharan, P L Nara, V M Caralli, F L Norton, N Haigwood, C Y Kang, Analysis of the cross-reactive anti-gp120 antibody population in human immunodeficiency virus-infected asymptomatic individuals. Journal of Virology. ,vol. 67, pp. 953- 960 ,(1993) , 10.1128/JVI.67.2.953-960.1993
Celia Ly, ChiChang Lee, Gordon Moore, Xiaomei Shi, Methods and compositions for enhanced protein expression and/or growth of cultured cells using co-transcription of a Bcl2 encoding nucleic acid ,(2001)