Process for the preparation of acetamide derivatives

作者: Jael Lexner , Ori Lerman , Shadi Saeed , Naim Menashe , Vladimir Naddaka

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摘要: PROCESS FOR THE PREPARATION OF ACETAMIDE DERIVATIVES ABSTRACT DISCLOSURE The invention provides a process for the preparation of diphenylmethylthioacetamide (I) as described in Scheme 4 comprising reacting isothiouronium salt or its corresponding base formula IV with an acetamide XCH2CONH2, wherein X represents halogen, M alkali metal and A anion, protic medium at temperature less than 100° C.