Process for the preparation of 2-[(diphenylmethyl) thio] acetamide

摘要: Process for the preparation of 2-[(diphenylmethyl)thioacetamide, an intermediate Modafinil which is a CNS stimulant and used treatment narcolepsia. The process comprises reacting 2-[(diphenylmethyl)thio]acetic acid with alcohols, in presence catalytic amount inorganic or organic at reflux temperature alcohol to obtain corresponding ester reacted ammonia give 2-[(diphenylmethyl)thio]acetamide. If desired 2-[(diphenylmethyl)thioacetamide thus produced hydrogen peroxide produce Modafinil.