Hypoxia induces H19 expression through direct and indirect Hif-1α activity, promoting oncogenic effects in glioblastoma.

作者: Weining Wu , Qi Hu , Er Nie , Tianfu Yu , Youzhi Wu

DOI: 10.1038/SREP45029

关键词:

摘要: … of H19 induction under hypoxia is partly accounted for by Hif-1α directly binding to the H19 … ) to be activated by Hif-1α, which enhances H19 transcriptional activation in glioblastoma cells…

参考文章(42)
Imad J. Matouk, Nathan DeGroot, Shaul Mezan, Suhail Ayesh, Rasha Abu-lail, Abraham Hochberg, Eithan Galun, The H19 Non-Coding RNA Is Essential for Human Tumor Growth PLoS ONE. ,vol. 2, pp. e845- ,(2007) , 10.1371/JOURNAL.PONE.0000845
Seung Kyoon Woo, Min Seong Kwon, Zhihua Geng, Zheng Chen, Alexander Ivanov, Sergei Bhatta, Volodymyr Gerzanich, J Marc Simard, Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8. Journal of Cerebral Blood Flow and Metabolism. ,vol. 32, pp. 525- 536 ,(2012) , 10.1038/JCBFM.2011.159
Kyvan Dang, Kenneth Myers, The role of hypoxia-induced miR-210 in cancer progression. International Journal of Molecular Sciences. ,vol. 16, pp. 6353- 6372 ,(2015) , 10.3390/IJMS16036353
H Choudhry, A Albukhari, M Morotti, S Haider, D Moralli, J Smythies, J Schödel, C M Green, C Camps, F Buffa, P Ratcliffe, J Ragoussis, A L Harris, D R Mole, Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene. ,vol. 34, pp. 4482- 4490 ,(2015) , 10.1038/ONC.2014.378
Yan Shi, Yingyi Wang, Wenkang Luan, Ping Wang, Tao Tao, Junxia Zhang, Jin Qian, Ning Liu, Yongping You, Long non-coding RNA H19 promotes glioma cell invasion by deriving miR-675. PLOS ONE. ,vol. 9, ,(2014) , 10.1371/JOURNAL.PONE.0086295
T Rosenberg, M Thomassen, SS Jensen, MJ Larsen, KP Sørensen, SK Hermansen, TA Kruse, BW Kristensen, Acute hypoxia induces upregulation of microRNA-210 expression in glioblastoma spheroids. CNS oncology. ,vol. 4, pp. 25- 35 ,(2015) , 10.2217/CNS.14.48
Junxia Zhang, Luyue Chen, Lei Han, Zhendong Shi, Jianning Zhang, Peiyu Pu, Chunsheng Kang, EZH2 is a negative prognostic factor and exhibits pro-oncogenic activity in glioblastoma Cancer Letters. ,vol. 356, pp. 929- 936 ,(2015) , 10.1016/J.CANLET.2014.11.003
Xia Ke, Fei Fei, Yanke Chen, Li Xu, Zheng Zhang, Qichao Huang, Hongxin Zhang, Hushan Yang, Zhinan Chen, Jinliang Xing, Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors Carcinogenesis. ,vol. 33, pp. 1598- 1607 ,(2012) , 10.1093/CARCIN/BGS196
Douglas S Micalizzi, Heide L Ford, Epithelial–mesenchymal transition in development and cancer Future Oncology. ,vol. 5, pp. 1129- 1143 ,(2009) , 10.2217/FON.09.94
I *Paul, S *Bhattacharya, A Chatterjee, MK Ghosh., *equal contribution, Current Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible Crosstalk Genes & Cancer. ,vol. 4, pp. 427- 446 ,(2013) , 10.1177/1947601913503341