Mycotoxins

摘要: Abstract Human exposure to mycotoxins can be determined by environmental and biological monitoring. Mycotoxins assume carcinogenic, mutagenic, teratogenic, immunotoxic properties, biomonitoring instruments applied assess their effects. Cytokinesis-block micronucleus assay is a method that allows cytological scoring of nuclear abnormalities resulting from genotoxic insult. Its use well established in in vitro genetic toxicology testing has become an accepted standard the hazard chemicals, which led development Organization for Economic Cooperation Development. Generally, citrin, patulin, ochratoxin, zearaleone genotoxicity are demonstrated increased presence micronucleus. The comet assay, assessing DNA damage, been widely used effects, namely owing oxidative using formamidopyrimidine glycosilase. Studies performed evaluate zearaleone, aflatoxin, citrinin, patulin demonstrate values parameters measured.