Natural history of normal-tension glaucoma.

摘要: Objective A recently reported randomized study described the role of intraocular pressure (IOP) in normal-tension glaucoma (NTG) pathogenesis and effect therapeutic lowering IOP. This is a report an analysis natural course NTG during time eyes were not receiving therapy, either interval awaiting randomization or after being randomly assigned to receive treatment lower Design Analysis prospectively collected data on long-term cohort untreated subjects with glaucoma, subset enrolled controlled clinical trial. RANDOMIZATION AND SUBJECT SELECTION: If field defect eye threatened point fixation, subject was start immediately be observed without until progression documented. Otherwise, only when if, subsequent enrollment, it showed visual progression, optic disc cupping, new hemorrhage. Participants Data for this 160 among total enrollment 260. They consist 49 who 24 followed later treatment, 31 similarly additional 56 but never assigned. Main outcome measures Visual used from which had been therapy analyzed by two progression: "survival" meeting criterion confirmed localized rate change mean deviation (MD) index over time. Results The four subgroups just similar at baseline, except that average MD slightly better progressed period follow-up. By Kaplan-Meier all combined, approximately one third within 3 years about half 5 7 years. Of more, 62 109 did show statistically significant negative slope regressed time, whereas others decline, mainly between -0.2 -2 db per year. Conclusions Some cases progress more rapidly than others. Although deterioration years, typically small slow, often insufficient measurably affect index.