Prognostic Significance of Human Epidermal Receptor (HER)- 3 Immunohistochemical Expression in Patients with Metastatic Breast Cancer

摘要: Background: Previous reports have shown that human epidermal receptor (HER)-3 overexpression may be associated with poor prognosis in patients breast cancer, but results been conflicting. In this study, we sought to investigate the prognostic significance of HER-3 immunohistochemical expression metastatic cancer. Methods: We retrospectively analyzed profiles 45 paraffin-embedded specimens from who had treated between 1996 and 2006 Department Oncology Uludag University School Medicine, Bursa, Turkey. Membranous or cytoplasmic dominant patterns were using Rajkumar score a 4-point scoring system, respectively. Progression-free survival (PFS) overall (OS) served as main outcome measures. Results: The median PFS study participants was 9 months (interquartile range: 4.5-13 months), whereas OS 20 7.5-28 months). Categorization patient population according positive did not reveal any statistically significant difference terms both (p=0.70) (p=0.81). multivariable Cox regression analysis indicated tumor size only independent predictor PFS, estrogen progesterone status independently OS. Conclusions: correlate outcomes Turkish Although our suggest cancer is significance, further prospective studies are warranted confirm these results.