Predictive value of menstrual cycle pattern, body mass index, hormone levels and polycystic ovaries at age 15 years for oligo‐amenorrhoea at age 18 years

摘要: BACKGROUND: On the question of how to counsel adolescents with irregular menstrual cycles or oligomenorrhoea, no clear answer has been given. Adolescents oligomenorrhoea especially show endocrine abnormalities and may be at risk for ovulatory dysfunction polycystic ovary syndrome in adulthood. METHODS: We followed a cohort document changes cycle pattern between ages 15 18 years general population. RESULTS: Two per cent (2/128) regular developed 12% (17/148) those did so. Fifty-one (34/67) oligomenorrhoeic remained oligomenorrhoeic. Increase body mass index (BMI), concentration LH, androstenedione testosterone, ovaries (PCO) were associated persistence oligomenorrhoea. In multivariate analysis only normal high BMI (>19.6 kg/m 2 ) consistently contributed significantly predict persistent Glucose:insulin ratio as marker insulin resistance was not an increased CONCLUSIONS: Oligomenorrhoea age is better predicted by than LH androgen concentrations PCO this age. Not obese, but also weight oligomenorrhoeic, have remaining