Naja naja karachiensis envenomation: biochemical parameters for cardiac, liver, and renal damage along with their neutralization by medicinal plants.
作者： Muhammad Hassham Hassan Bin Asad , Ghulam Murtaza , Muhammad Ubaid , Ashif Sajjad , Rubada Mehmood
DOI: 10.1155/2014/970540
关键词:
摘要: Naja naja karachiensis envenomation was found to hit more drastically heart, liver, and kidneys. 400 μg/kg of venom-raised moderate serum levels ALT (72 ± 4.70 U/L, 0.1 > P 0.05), AST (157 24.24 urea (42 3.08 mg/dL, 0.05 0.02), creatinine (1.74 0.03 0.01 0.001), CK-MB (21 1.5 LDH (2064 15.98 (251 18.2 (57.6 3.84 0.02 0.01), (2.1 0.10 (77 11.22 (2562 25.14 ≪ 0.001). Among twenty-eight tested medicinal plant extracts, only Stenolobium stans (L.) Seem the best antivenom (P 0.5) compared efficacy standard antidote (ALT = 52.5 3.51 69.5 18.55 31.5 0.50 1.08 09 0.85 763 6.01 U/L). Other extracts were proved less beneficial partly neutralized toxicities posed by cobra venom. However, it is essential in future isolate characterize bioactive compound(s) from extract overcome complications snake bite.
hindawi.com参考文章(39)
Qazi Najam-Us-saqib, Sabiha Karim, Muhammad Tahir Razi, Muhammad Hassham Hassan Bin Asad, Taous Khan, Izhar Hussain, Ghulam Murtaza, Muhammad Shahzad Hussain, Muhammad Sikandar Hussain, Coagulopathies in Naja naja karachiensis (black Pakistan cobra) bites and its effect on coagulation tests upon storage of platelet-poor plasma. Acta Poloniae Pharmaceutica. ,vol. 69, pp. 1031- 1034 ,(2012)
T. R. Rahmy, K. Z. Hemmaid, Histological and histochemical alterations in the liver following intramuscular injection with a sublethal dose of the Egyptian cobra venom. Journal of Natural Toxins. ,vol. 9, pp. 21- 32 ,(2000)
A. Trocino, M. Cerioli, S. D. Lukefahr, A. Lavazza, G. Grilli, G. Xicato, I. Archetti, C. Tittarelli, R. Brivio, Serum chemistry and hematology values in commercial rabbits: preliminary data from industrial farms in Northern Italy. Proceedings of the 9th World Rabbit Congress, Verona, Italy, 10-13 June 2008. pp. 1147- 1152 ,(2008)
Bhadrapura L Dhananjaya, Cletus JM D’Souza, None, The Pharmacological Role of Phosphatases (Acid and Alkaline Phosphomonoesterases) in Snake Venoms related to Release of Purines - a Multitoxin Basic & Clinical Pharmacology & Toxicology. ,vol. 108, pp. 79- 83 ,(2011) , 10.1111/J.1742-7843.2010.00630.X
S. VandeWoude, P. V. Turner, J. E. Harkness, C. L. Wheler, Harkness and Wagner's Biology and Medicine of Rabbits and Rodents ,(2010)
Q. LU, J. M. CLEMETSON, K. J. CLEMETSON, Snake venoms and hemostasis. Journal of Thrombosis and Haemostasis. ,vol. 3, pp. 1791- 1799 ,(2005) , 10.1111/J.1538-7836.2005.01358.X
Silke Ehrenforth, Joachim Schenk, Inge Scharrer, Liver damage induced by coumarin anticoagulants. Seminars in Thrombosis and Hemostasis. ,vol. 25, pp. 79- 83 ,(1999) , 10.1055/S-2007-996428
Himatkumar V. Patel, Alka A. Vyas, Kavita A. Vyas, Yi-Shiuan Liu, Chien-Min Chiang, Lang-Ming Chi, Wen-guey Wu, Heparin and heparan sulfate bind to snake cardiotoxin. Sulfated oligosaccharides as a potential target for cardiotoxin action. Journal of Biological Chemistry. ,vol. 272, pp. 1484- 1492 ,(1997) , 10.1074/JBC.272.3.1484
Mukesh Nandave, Shreesh K. Ojha, Sujata Joshi, Santosh Kumari, Dharamvir S. Arya, Cardioprotective Effect of Bacopa monneira Against Isoproterenol-Induced Myocardial Necrosis in Rats International Journal of Pharmacology. ,vol. 3, pp. 385- 392 ,(2007) , 10.3923/IJP.2007.385.392
Mohammad H. Pipelzadeh, Amir Jalali, Mohammad Taraz, Roya Pourabbas, Abbas Zaremirakabadi, An epidemiological and a clinical study on scorpionism by the Iranian scorpion Hemiscorpius lepturus. Toxicon. ,vol. 50, pp. 984- 992 ,(2007) , 10.1016/J.TOXICON.2007.07.018