Honey shows potent inhibitory activity against the bovine testes hyaluronidase

作者: Sevgi Kolayli , Huseyin Sahin , Zehra Can , Oktay Yildiz , Kübra Sahin

DOI: 10.3109/14756366.2015.1054819

关键词:

摘要: The purpose of this study was to investigate the anti-hyaluronidase activities honeys from different botanical origins in order determine their anti-inflammatory properties. total phenolic contents, flavonoids and tannin levels six types honey, chestnut, oak, heather, pine, buckwheat mixed blossom, were determined. Concentration-related inhibition values tested turbidimetrically on bovine testis hyaluronidase (BTHase) as IC50 (mg/mL). All exhibited various concentration-dependent degrees against BTHase. Inhibition varied significantly depending honeys' flavonoid tannin. with highest activity chestnut heather. In conclusion, polyphenol-rich have high activity, these protective complementary potential hyaluronidase-induced failures.

参考文章(32)
J. Louveaux, Anna Maurizio, G. Vorwohl, Methods of Melissopalynology Bee World. ,vol. 59, pp. 139- 157 ,(1978) , 10.1080/0005772X.1978.11097714
Zehra Can, Oktay Yildiz, Huseyin Sahin, Emine Akyuz Turumtay, Sibel Silici, Sevgi Kolayli, An investigation of Turkish honeys: their physico-chemical properties, antioxidant capacities and phenolic profiles. Food Chemistry. ,vol. 180, pp. 133- 141 ,(2015) , 10.1016/J.FOODCHEM.2015.02.024
S. Ülgentürk, F. Szentkirályi, N. Uygun, M. Fent, S. D. Gaimari, H. Civelek, B. Ayhan, Predators of Marchalina hellenica (Hemiptera: Marchalinidae) on pine forests in Turkey Phytoparasitica. ,vol. 41, pp. 529- 537 ,(2013) , 10.1007/S12600-013-0313-1
José R. Soberón, Melina A. Sgariglia, Diego A. Sampietro, Emma N. Quiroga, Marta A. Vattuone, Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius. Journal of Ethnopharmacology. ,vol. 130, pp. 329- 333 ,(2010) , 10.1016/J.JEP.2010.05.015
O. Yildiz, F. Karahalil, Z. Can, H. Sahin, S. Kolayli, Total monoamine oxidase (MAO) inhibition by chestnut honey, pollen and propolis Journal of Enzyme Inhibition and Medicinal Chemistry. ,vol. 29, pp. 690- 694 ,(2014) , 10.3109/14756366.2013.843171
Riitta Julkunen-Tiitto, Phenolic constituents in the leaves of northern willows: methods for the analysis of certain phenolics Journal of Agricultural and Food Chemistry. ,vol. 33, pp. 213- 217 ,(1985) , 10.1021/JF00062A013
A.F. Wahby, El-Sayed M.E. Mahdy, Hatem A. EL-mezayen, Walaa H. Salama, Nihal M. Ebrahim, Azza M. Abdel-Aty, Afaf S. Fahmy, Role of hyaluronidase inhibitors in the neutralization of toxicity of Egyptian horned viper Cerastes cerastes venom Journal of Genetic Engineering and Biotechnology. ,vol. 10, pp. 213- 219 ,(2012) , 10.1016/J.JGEB.2012.10.001
L. R. Fukumoto, G. Mazza, Assessing antioxidant and prooxidant activities of phenolic compounds. Journal of Agricultural and Food Chemistry. ,vol. 48, pp. 3597- 3604 ,(2000) , 10.1021/JF000220W
U.R. Kuppusamy, H.E. Khoo, N.P. Das, Structure-activity studies of flavonoids as inhibitors of hyaluronidase. Biochemical Pharmacology. ,vol. 40, pp. 397- 401 ,(1990) , 10.1016/0006-2952(90)90709-T