Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile

摘要: Abstract Background and aims The components of the renin-angiotensin system in leukocytes is involved pathophysiology non-communicable diseases (NCDs), including hypertension, atherosclerosis chronic kidney disease. Angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP) an AT1R-specific binding protein, able to inhibit pathological activation AT1R signaling certain animal models NCDs. aim present study was investigate expression regulation ATRAP leukocytes. Methods Human leukocyte mRNA measured with droplet digital polymerase chain reaction system, analyzed relation clinical variables. We also examined cytokines bone-marrow ATRAP-deficient wild-type chimeric mice after injection low-dose lipopolysaccharide. Results abundantly expressed leukocytes, predominantly granulocytes monocytes, healthy subjects. In 86 outpatients NCDs, levels correlated positively granulocyte monocyte counts serum C-reactive levels. These positive relationships remained significant even adjustment. Furthermore, significantly associated interleukin-1β, tumor necrosis factor-α chemotactic protein-1 NCDs patients. addition, interleukin-1β level upregulated bone marrow comparison Conclusions results suggest that emerging marker capable reflecting systemic inflammatory profile, plays a role as anti-inflammatory factor