Role of Hyaluronan Metabolism in the Initiation, Invasion, and Metastasis of Breast Cancer

摘要: Publisher Summary The evolutionary process of breast cancer involves progression through defined pathological and clinical stages, initiating with ductal hyperproliferation, subsequent development into in situ invasive carcinomas, finally metastatic disease. This chapter focuses on the intratumoral metabolism extracellular matrix (ECM) glycosaminoglycan, hyaluronan (HA), role that anabolic catabolic products play initiation, progression, invasion cancer. dynamic balance between HA synthesis degradation within tumor microenvironment plays an integral complex, multistep carcinogenesis. Substantial preclinical work has elegantly elucidated potential participation both synthetic degradative enzymes metabolic processes Tumor maintenance appear to be highly dependent accumulation high MW stroma, where it provides a hydrated growth for cells, promotes survival by prevention apoptosis, camouflages cells from cytotoxic attack host immunocompetent ultimately stimulates invasion. specific signaling events induce neovascularization, lymphangiogenesis, ECM via enhanced expression metalloproteinases. Numerous cellular ligands molecules have been shown participate carcinogenesis breast, but complete understanding significance translation benefit requires substantially more elucidation.