Angiogenic oligosaccharides of hyaluronan enhance the production of collagens by endothelial cells
作者： S. Kumar , P. Kumar , P. Rooney , M. Wang
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摘要: The present study demonstrates a relationship between angiogenic oligosaccharides of hyaluronan (HA) and the production collagens during process angiogenesis in vivo vitro. addition HA to chorioallantoic membrane chick embryo induced deposition collagen fibrils. treatment sub-confluent cultures bovine aortic endothelial cells with same (1 microgram/ml) increased uptake [3H]proline by approximately 60%. SDS-polyacrylamide gel electrophoresis treated demonstrated enhanced synthesis type I VIII collagens. was confirmed western blotting immunocytochemistry using antibodies sheep collagen. Type is short chain that has high degree homology cartilage-specific X biological functions are unknown. We have suggested two play role angiogenesis.
biologists.org参考文章(38)
A M Dvorak, V S Harvey, P Estrella, L F Brown, H F Dvorak, J McDonagh, Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Laboratory Investigation. ,vol. 57, pp. 673- 686 ,(1987)
P D Benya, S R Padilla, Isolation and characterization of type VIII collagen synthesized by cultured rabbit corneal endothelial cells. A conventional structure replaces the interrupted-helix model. Journal of Biological Chemistry. ,vol. 261, pp. 4160- 4169 ,(1986) , 10.1016/S0021-9258(17)35640-5
N Yamaguchi, R Mayne, Y Ninomiya, The alpha 1 (VIII) collagen gene is homologous to the alpha 1 (X) collagen gene and contains a large exon encoding the entire triple helical and carboxyl-terminal non-triple helical domains of the alpha 1 (VIII) polypeptide. Journal of Biological Chemistry. ,vol. 266, pp. 4508- 4513 ,(1991) , 10.1016/S0021-9258(20)64352-6
N Yamaguchi, P D Benya, M van der Rest, Y Ninomiya, The cloning and sequencing of α1(VIII) collagen cDNAs demonstrate that type VIII collagen is a short chain collagen and contains triple-helical and carboxyl-terminal non-triple-helical domains similar to those of type X collagen Journal of Biological Chemistry. ,vol. 264, pp. 16022- 16029 ,(1989) , 10.1016/S0021-9258(18)71582-2
K Alitalo, P Bornstein, A Vaheri, H Sage, Biosynthesis of an unusual collagen type by human astrocytoma cells in vitro. Journal of Biological Chemistry. ,vol. 258, pp. 2653- 2661 ,(1983) , 10.1016/S0021-9258(18)32976-4
H Sage, B Trüeb, P Bornstein, Biosynthetic and structural properties of endothelial cell type VIII collagen. Journal of Biological Chemistry. ,vol. 258, pp. 13391- 13401 ,(1983) , 10.1016/S0021-9258(17)44129-9
HELENE SAGE, MARIA-LUISA IRUELA-ARISPE, Type VIII collagen in murine development : association with capillary formation in vitro Annals of the New York Academy of Sciences. ,vol. 580, pp. 17- 31 ,(1990) , 10.1111/J.1749-6632.1990.TB17914.X
C M Kielty, A P L Kwan, D F Holmes, S L Schor, M E Grant, Type X collagen, a product of hypertrophic chondrocytes Biochemical Journal. ,vol. 227, pp. 545- 554 ,(1985) , 10.1042/BJ2270545
Hajime Sawada, The fine structure of the bovine Descemet's membrane with special reference to biochemical nature. Cell and Tissue Research. ,vol. 226, pp. 241- 255 ,(1982) , 10.1007/BF00218356
C STERN, Mini-review: Hyaluronidases in early embryonic development Cell Biology International Reports. ,vol. 8, pp. 703- 717 ,(1984) , 10.1016/0309-1651(84)90108-5