Postconditioning in acute myocardial infarction patients.
作者： Fabrice Ivanes , Gilles Rioufol , Christophe Piot , Michel Ovize
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摘要: Abstract Reperfusion therapy is the indispensable treatment of acute myocardial infarction (AMI) and must be applied as soon possible to attenuate ischemic insult. Evidence indicates that reperfusion responsible for additional damage likely involving opening mitochondrial permeability transition pore. Ischemic postconditioning a new way dramatically reduce lethal injury. Several clinical studies using angioplasty now support its protective effects in patients with an AMI. An interesting alternative pharmacological postconditioning, which could much larger number patients. The pore inhibitor cyclosporine A has been shown generate comparable protection AMI Future large-scale trials are needed determine whether may improve outcome ST-segment elevation MI Antioxid. Redox Signal. 14, 811–820.
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