MicroRNA-101 inhibits cell progression and increases paclitaxel sensitivity by suppressing MCL-1 expression in human triple-negative breast cancer

摘要: Triple-negative breast cancer is the most aggressive subtype. The aim of our study was to investigate functional role both miR-101 and MCL-1 in sensitivity human triple-negative (TNBC) paclitaxel. We found that expression strongly decreased tissues cell lines. not associated with clinical stage or lymph node infiltration TNBC. Ectopic overexpression inhibit growth induced apoptosis vitro suppressed tumorigenicity vivo. significantly overexpressed TNBC Luciferase assay results confirmed as a direct target gene miR-101. MiR-101 inhibited cells transplanted tumors. There negative correlation between level tissues. Suppression enhanced MDA-MB-435 Furthermore, increased paclitaxel by inhibiting expression. Our findings provide significant insight into molecular mechanisms carcinogenesis may have relevance for development novel, targeted therapies