Regulation of epithelial-mesenchymal transition through microRNAs: clinical and biological significance of microRNAs in breast cancer.
作者： Fu Peng , Liang Xiong , Hailin Tang , Cheng Peng , Jianping Chen
DOI: 10.1007/S13277-016-5334-1
关键词:
摘要: Breast cancer is a malignant disease to treat among female worldwide due its high capability metastasize and mutate. Epithelial-mesenchymal transition one of the essential processes involved in metastatic capacity breast cancer. In recent time, studies demonstrate that microRNAs, kind small non-coding RNA molecules, could be served as negative regulators cancer, regulating cell cycle, drug resistance, process metastasis development. With assistance microRNA profiling, study concentrating on regulatory function miRNAs investigated more effectively efficiently. More have an important role play EMT modulate metastasis. This essay purpose demonstrating significance detection oncogenes tumor suppress genes through miRNA profiling according reports mainly 5 years, providing evidence efficient target therapy effective pro-diagnosis focusing expression patients.
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